I tried using CrossOver to run Office 2007 a year ago, and while it basically worked I found it was just as good if not better to run Windows in VirtualBox (and I don't even have VM instructions on my processor).
True, though you can still use VMWare Converter [1] image your OEM install and then run it in a vm. You just get the constant reminders that Windows is not authentic and you should activate it.
I haven't looked at it lately, but I think one reason I used to run Wine instead of a VM was that Wine gives better 3d support for games. I even ran EVE for a while, before I realized that Wine wasn't able to draw the lasers pew-pewing from my ship, which made things kind of boring.
Now to go search and see if Wine 1.4 works on FreeBSD at all.