This approach is fine until you try to include an IC in your design, at which point you have only an extremely limited version (if any) available for simulation.
I worked at a product design consultancy and saw a number of board designs come through the office. All of them had a prototype run of 3-6 boards, which ended up with one or two modification wires before a second, final, production run was done.
That's another wrinkle. Because boards are so expensive and turnaround's so long you typically want to rework them when possible to validate changes. That takes a talented technician, fairly expensive equipment and time. Reworking e.g. a dozen boards can take days.
I worked at a product design consultancy and saw a number of board designs come through the office. All of them had a prototype run of 3-6 boards, which ended up with one or two modification wires before a second, final, production run was done.